Basic Information
LncRNA/CircRNA Name | H19 |
Synonyms | H19, ASM, ASM1, BWS, D11S813E, LINC00008, NCRNA00008, WT2 |
Region | GRCh38_11:1995176-2001470 |
Ensemble | ENSG00000130600 |
Refseq | NR_002196 |
Classification Information
Regulatory Mechanism | Biological Function | Clinical Application | |||
---|---|---|---|---|---|
TF | Immune | Survival | |||
Enhancer | Apoptosis | Drug | |||
Variant | Cell Growth | Circulating | |||
MiRNA | EMT | Metastasis | |||
Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
Cancer Name | breast cancer |
ICD-0-3 | C50 |
Methods | qPCR, Western blot, Luciferase report assay |
Sample | The human breast cancer cell lines (MCF-7 ,MDA-MB-231), human breast tumor tissues |
Expression Pattern | up-regulated |
Function Description | In conclusion, H19 promoted proliferation and invasion of breast cancer through the miR-152/DNMT1 axis, providing a novel mechanism about the occurrence and development of breast cancer. |
Pubmed ID | 28544374 |
Year | 2017 |
Title | Long non-coding RNA H19 promotes the proliferation and invasion of breast cancer through upregulating DNMT1 expression by sponging miR-152. |
External Links
Links for H19 | GenBank HGNC NONCODE |
Links for breast cancer | OMIM COSMIC |