Basic Information
| LncRNA/CircRNA Name | H19 |
| Synonyms | H19, ASM, ASM1, BWS, D11S813E, LINC00008, NCRNA00008, WT2 |
| Region | GRCh38_11:1995176-2001470 |
| Ensemble | ENSG00000130600 |
| Refseq | NR_002196 |
| Regulatory Mechanism | Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Information of Cancer
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, RNAi etc. |
| Sample | cell lines (AGS1, MGC803, SGC7901, and MKN46), gastric adenocarcinomas tissues |
| Expression Pattern | up-regulated |
| Function Description | lncRNAs H19,MEG3 and MALAT1 showed significant association with tumor stage and HOTAIR had a significant association with patient survival.H19 is a well-known oncogenic lncRNA that is involved in the reduction of p53 activity inducing proliferation in gastric cancer.In the present study,we observed a higher level of H19 which sponged out the low level expressed miR-148a leading to the overexpression of its target mRNA DNMT1.Similarly,we also observed the KLF4 overexpression due to the H19 mediated sponging of miR-148a. |
| Pubmed ID | 29719612 |
| Year | 2018 |
| Title | Comprehensive analysis of aberrantly expressed lncRNAs and construction of ceRNA network in gastric cancer. |
External Links
| Links for H19 | GenBank HGNC Noncode |
| Links for gastric cancer | Omim Cosmic |