Basic Information
| LncRNA/CircRNA Name | H19 |
| Synonyms | H19, ASM, ASM1, BWS, D11S813E, LINC00008, NCRNA00008, WT2 |
| Region | GRCh38_11:1995176-2001470 |
| Ensemble | ENSG00000130600 |
| Refseq | NR_002196 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, RIP, Luciferase reporter assay, in vitro knockdown etc. |
| Sample | gastric cancer tissues,cell lines (AGS, MKN45, MGC803, SGC7901, GES-1 etc.) |
| Expression Pattern | up-regulated |
| Function Description | We demonstrated that H19 levels were markedly increased in gastric cancer cells and gastric cancer tissues compared with normal controls. Moreover, ectopic expression of H19 increased cell proliferation, whereas H19 siRNA treatment contributed to cell apoptosis in AGS cell line. We further verified that H19 was associated with p53, and that this association resulted in partial p53 inactivation. |
| Pubmed ID | 22776265 |
| Year | 2012 |
| Title | Up-regulated long non-coding RNA H19 contributes to proliferation of gastric cancer cells. |
External Links
| Links for H19 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |