Basic Information
| LncRNA/CircRNA Name | H19 |
| Synonyms | H19, ASM, ASM1, BWS, D11S813E, LINC00008, NCRNA00008, WT2 |
| Region | GRCh38_11:1995176-2001470 |
| Ensemble | ENSG00000130600 |
| Refseq | NR_002196 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | bladder cancer |
| ICD-0-3 | C67 |
| Methods | qPCR, RNAi, Western blot etc. |
| Sample | cell line (HTB-9, J82), bladder cancer tissues |
| Expression Pattern | up-regulated |
| Function Description | Up-regulation of H19 in bladder cancer tissues is correlated with clinical stage or metastasis of cancer.By cell transfection to suppress H19 expression in bladder cancer cells,E-cadherin expression is upregulated,thus weakening metastatic potency of cancer cells. |
| Pubmed ID | 29614625 |
| Year | 2018 |
| Title | Inhibition of E-cadherin expression by lnc-RNA H19 to facilitate bladder cancer metastasis. |
External Links
| Links for H19 | GenBank HGNC NONCODE |
| Links for bladder cancer | OMIM COSMIC |