Basic Information
| LncRNA/CircRNA Name | H19 |
| Synonyms | H19, ASM, ASM1, BWS, D11S813E, LINC00008, NCRNA00008, WT2 |
| Region | GRCh38_11:1995176-2001470 |
| Ensemble | ENSG00000130600 |
| Refseq | NR_002196 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qRT-PCR, Luciferase reporter assay |
| Sample | glioma tissues, human glioma cell lines (A172, U251, U87, U373 and U563) |
| Expression Pattern | up-regulated |
| Function Description | H19 expression was upregulated and miR 152 expression was downregulated in human glioma cell lines.H19 downregulation or miR-152 upregulation suppressed glioma cell proliferation and invasion in vitro.Moreover, H19 and miR-152 directly regulated each other.Furthermore,decreased miR-152 expression alleviated si-H19-induced inhibitory effects on proliferation and invasion in glioma cells.As expected, H19 silencing hindered glioma growth in vivo. |
| Pubmed ID | 29422115 |
| Year | 2018 |
| Title | Long non-coding RNA H19 promotes proliferation and invasion in human glioma cells by downregulating miR-152. |
External Links
| Links for H19 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |