Basic Information
| LncRNA/CircRNA Name | H19 |
| Synonyms | H19, ASM, ASM1, BWS, D11S813E, LINC00008, NCRNA00008, WT2 |
| Region | GRCh38_11:1995176-2001470 |
| Ensemble | ENSG00000130600 |
| Refseq | NR_002196 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioblastoma |
| ICD-0-3 | NA |
| Methods | qPCR, RNAi, Cell migration and invasion assay etc. |
| Sample | glioblastoma tissues, cell lines (U87, U373) |
| Expression Pattern | up-regulated |
| Function Description | H19 is significantly overexpressed in glioblastoma tissues. Overexpression of H19 promotes glioblastoma cell invasion and angiogenesis in vitro. Interestingly, H19 was also significantly overexpressed in CD133+ glioblastoma cells, and overexpression of H19 was associated with increased neurosphere formation of glioblastoma cells. Finally, stable overexpression of H19 was associated with increased tumor growth in the murine xenograft model. |
| Pubmed ID | 28306408 |
| Year | 2017 |
| Title | Increased level of H19 long noncoding RNA promotes invasion, angiogenesis, and stemness of glioblastoma cells. |
External Links
| Links for H19 | GenBank HGNC NONCODE |
| Links for glioblastoma | OMIM COSMIC |