Basic Information
| LncRNA/CircRNA Name | H19 |
| Synonyms | H19, ASM, ASM1, BWS, D11S813E, LINC00008, NCRNA00008, WT2 |
| Region | GRCh38_11:1995176-2001470 |
| Ensemble | ENSG00000130600 |
| Refseq | NR_002196 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colon cancer |
| ICD-0-3 | C18 |
| Methods | qPCR, Western blot etc. |
| Sample | colorectal cancer tissues, cell lines (HCT-116 and SW-481) |
| Expression Pattern | up-regulated |
| Function Description | overexpression of H20 is associated with decreased recurrence-free survival and overall survival rates in patients with colorectal cancer, and increased viability and migration in colon cancer cells. H19 may function as a competing endogenous RNA for miR-138 and miR-200a, antagonizing their functions and thus leading to the derepression of their endogenous targets vimentin, zinc finger E-box-binding homeobox (ZEB) OL-9705-NPS 1 and ZEB2, all of which were associated with the EMT process. |
| Pubmed ID | 28781681 |
| Year | 2017 |
| Title | Overexpression of long non-coding RNA H20 is associated with unfavorable prognosis in patients with colorectal cancer and increased proliferation and migration in colon cancer cells. |
External Links
| Links for H19 | GenBank HGNC NONCODE |
| Links for colon cancer | OMIM COSMIC |