Basic Information
| LncRNA/CircRNA Name | H19 |
| Synonyms | H19, ASM, ASM1, BWS, D11S813E, LINC00008, NCRNA00008, WT2 |
| Region | GRCh38_11:1995176-2001470 |
| Ensemble | ENSG00000130600 |
| Refseq | NR_002196 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colon cancer |
| ICD-0-3 | C18 |
| Methods | qPCR, Cell transfection, Western blot, ChIP, Luciferase reporter assay, MTT assay etc. |
| Sample | colon cancer tissues, cell lines (HT-29 and DLD-1) |
| Expression Pattern | up-regulated |
| Function Description | VDR signaling was able to inhibit the expression of H19 through regulating C-Myc/Mad-1 network.H19, on the other hand, was able to inhibit the expression of VDR through micro RNA 675-5p (miR-675-5p). Furthermore, H19 overexpression induced resistance to the treatment with 1,25(OH)2D3 both in vitro and in vivo. |
| Pubmed ID | 28189050 |
| Year | 2017 |
| Title | H19 Overexpression Induces Resistance to 1,25(OH)2D3 by Targeting VDR Through miR-675-5p in Colon Cancer Cells. |
External Links
| Links for H19 | GenBank HGNC NONCODE |
| Links for colon cancer | OMIM COSMIC |