Basic Information
| LncRNA/CircRNA Name | H19 |
| Synonyms | H19, ASM, ASM1, BWS, D11S813E, LINC00008, NCRNA00008, WT2 |
| Region | GRCh38_11:1995176-2001470 |
| Ensemble | ENSG00000130600 |
| Refseq | NR_002196 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | wilms tumor |
| ICD-0-3 | C64.9 |
| Methods | qPCR etc. |
| Sample | Wilms tumor tissues |
| Expression Pattern | differential expression |
| Function Description | Investigating the methylation status of H19DMR revealed a balanced distribution of LOI, ROI and LOH for WT samples. Two-thirds had alterations in H19DMR methylation. Among these samples, 11 had LOI and another 11 LOH. ROI was evident for the remaining 10 tissues. Interestingly, two samples of the nine normal renal tissues had LOI in their H19DMR, while the other ones had ROI. |
| Pubmed ID | 21174059 |
| Year | 2011 |
| Title | Altered expression of imprinted genes in Wilms tumors. |
External Links
| Links for H19 | GenBank HGNC NONCODE |
| Links for wilms tumor | OMIM COSMIC |