Basic Information
| LncRNA/CircRNA Name | AK023391 |
| Synonyms | NA |
| Region | GRCh_8:123500153-123501863 |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Microarray, western blot |
| Sample | gastric cancer tissues, cell lines(HGC-27, AGS, SGC-7901,BGC-823, and MGC-803,GES-1) |
| Expression Pattern | up-regulated |
| Function Description | Expression of lncRNA AK023391 was significantly upregulated in gastric cancer samples and cell lines in comparison to adjacent normal tissues, and was positively correlated with poor survival in patients with gastric cancer.AK023391 expression acted as an independent prognostic factor for survival in patients with gastric cancer. Knockdown of AK023391 inhibited cell growth and invasion both in vitro and in vivo, and induced apoptosis and cell cycle arrest in gastric cancer cells,whereas its overexpression reversed these effects. PI3K/Akt signaling mediated the NF-kB, FOXO3a, and p53 pathways. Moreover,downstream transcription factors, such as c-myb, cyclinB1/G2, and BCL-6 might be involved in AK023391-induced tumorigenesis in gastric cancer. |
| Pubmed ID | 29282102 |
| Year | 2017 |
| Title | LncRNA AK023391 promotes tumorigenesis and invasion of gastric cancer through activation of the PI3K/Akt signaling pathway. |
External Links
| Links for AK023391 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |