Basic Information
| LncRNA/CircRNA Name | H19 |
| Synonyms | H19, ASM, ASM1, BWS, D11S813E, LINC00008, NCRNA00008, WT2 |
| Region | GRCh38_11:1995176-2001470 |
| Ensemble | ENSG00000130600 |
| Refseq | NR_002196 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | thyroid cancer |
| ICD-0-3 | C73.9 |
| Methods | qPCR, Luciferase reporter assay etc. |
| Sample | thyroid cancer tissues, cell lines (TPC-1, NIM, Nthy-ori 3-1 and BCPAP) |
| Expression Pattern | up-regulated |
| Function Description | Our results suggest that H19 functions as a competitive endogenous RNA (ceRNA) by acting as a sink for miR-17-5p, revealing a potential ceRNA regulatory network involving H19 and miR-17-5p with a role in the modulation of YES1 expression. This mechanism may contribute to a better understanding of thyroid cancer pathogenesis and provide new insights into the treatment of this disease. |
| Pubmed ID | 27093644 |
| Year | 2016 |
| Title | Long noncoding RNA H19 competitively binds miR-17-5p to regulate YES1 expression in thyroid cancer |
External Links
| Links for H19 | GenBank HGNC NONCODE |
| Links for thyroid cancer | OMIM COSMIC |