Basic Information
| LncRNA/CircRNA Name | H19 |
| Synonyms | H19, ASM, ASM1, BWS, D11S813E, LINC00008, NCRNA00008, WT2 |
| Region | GRCh38_11:1995176-2001470 |
| Ensemble | ENSG00000130600 |
| Refseq | NR_002196 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | qPCR, RNAi, RIP, ChIP, Flow cytometry assay etc. |
| Sample | cell line (MG63) |
| Expression Pattern | up-regulated |
| Function Description | H19 is overexpressed after transfection with H19 lentivirus in MG63 cells, while silenced after transfection with shH19 lentivirus. Functionally, overexpression of H19 promoted cell migration and invasion of MG63 cells compared with the control. Furthermore, we showed that H19 promotes metastasis through upregulation of ZEB1 and ZEB2 by competitively binding the miR-200 family. |
| Pubmed ID | 27008415 |
| Year | 2016 |
| Title | H19 Functions as a ceRNA in Promoting Metastasis Through Decreasing miR-200s Activity in Osteosarcoma. |
External Links
| Links for H19 | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |