Basic Information
| LncRNA/CircRNA Name | H19 |
| Synonyms | H19, ASM, ASM1, BWS, D11S813E, LINC00008, NCRNA00008, WT2 |
| Region | GRCh38_11:1995176-2001470 |
| Ensemble | ENSG00000130600 |
| Refseq | NR_002196 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, MTT assay etc. |
| Sample | cell line (hFOB1.19) |
| Expression Pattern | down-regulated |
| Function Description | Both H19 and miR-675 levels in hFOB1.19 cells were significantly decreased by overexpression of miR-141 than that in control group, but their expression were reversed by miR-141 inhibitor. In addition, expression of H19 and miR-675 in adjacent tissues were both significantly higher than that in tumor tissues. However, cell viability was significantly decreased by co-transfection of siRNA-H19/miR-675 inhibitor and miR-141 inhibitor compared with the miR-141 inhibitor group with time increasing, suggesting that the promote role of miR-141 inhibitor on cell proliferation may be suppressed by silencing H19 or miR-675 inhibitor. |
| Pubmed ID | 27186302 |
| Year | 2016 |
| Title | miR-141 modulates osteoblastic cell proliferation by regulating the target gene of lncRNA H19 and lncRNA H19-derived miR-675. |
External Links
| Links for H19 | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |