Basic Information
| LncRNA/CircRNA Name | H19 |
| Synonyms | H19, ASM, ASM1, BWS, D11S813E, LINC00008, NCRNA00008, WT2 |
| Region | GRCh38_11:1995176-2001470 |
| Ensemble | ENSG00000130600 |
| Refseq | NR_002196 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cholangiocarcinoma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot etc. |
| Sample | CCA tissue, cell lines (RBE, HCCC-9810, QBC939, Huh-28, HuCCT1, KMBC and CCLP-1) |
| Expression Pattern | up-regulated |
| Function Description | expression levels of H19 were investigated in CCA tissues and cell lines and were correlated with clinicopathological features.H19 was upregulated in CCA tissue samples and cell lines, and this upregulation was associated with tumor size,TNM stage, postoperative recurrence and overall survival in 56 patients with CCA. knockdown of H19 followed by RNA silencing restrained cell proliferation and promoted apoptosis.In addition,H19 suppression impaired migration and invasion potential by reversing EMT. Overall, our findings may help to develop diagnostic biomarkers and therapeutics that target H19 for the treatment of CCA. H19 acts as a tumor-promoting role by regulating miR-675 in gastric cancer cells, indicating a correlation between H19 and miRNAs in cancer cells. |
| Pubmed ID | 28528181 |
| Year | 2017 |
| Title | Overexpression of long noncoding RNA H19 indicates a poor prognosis for cholangiocarcinoma and promotes cell migration and invasion by affecting epithelial-mesenchymal transition. |
External Links
| Links for H19 | GenBank HGNC NONCODE |
| Links for cholangiocarcinoma | OMIM COSMIC |