Basic Information
| LncRNA/CircRNA Name | H19 |
| Synonyms | H19, ASM, ASM1, BWS, D11S813E, LINC00008, NCRNA00008, WT2 |
| Region | GRCh38_11:1995176-2001470 |
| Ensemble | ENSG00000130600 |
| Refseq | NR_002196 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | prostate cancer |
| ICD-0-3 | C61.9 |
| Methods | qPCR, ISH etc. |
| Sample | cell lines (PNT1A, LNCaP, DU-145) |
| Expression Pattern | up-regulated |
| Function Description | PRL increased H19 expression, but DHT reduced it. The combination of the two hormones revealed DHT to be a potent inhibitor of the peptidic hormone effect in H19 gene expression. Interestingly, this latter range of in vitro results obtained after hormone treatments of LNCaP cells is in agreement with ISH observations made on the rat prostate epithelial cells. |
| Pubmed ID | 15525575 |
| Year | 2004 |
| Title | Hormonal regulation of H19 gene expression in prostate epithelial cells. |
External Links
| Links for H19 | GenBank HGNC NONCODE |
| Links for prostate cancer | OMIM COSMIC |