Basic Information
| LncRNA/CircRNA Name | H19 |
| Synonyms | H19, ASM, ASM1, BWS, D11S813E, LINC00008, NCRNA00008, WT2 |
| Region | GRCh38_11:1995176-2001470 |
| Ensemble | ENSG00000130600 |
| Refseq | NR_002196 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | esophageal cancer |
| ICD-0-3 | C15 |
| Methods | qPCR, RNAi, Western blot etc. |
| Sample | esophageal cancer tissues, cell lines (TE-1, TE-10, Eca-1, Eca-109, KYSE1170) |
| Expression Pattern | up-regulated |
| Function Description | The expression of H19 was significantly increased and associated with tumor depth and metastasis in 133 EC samples. In addition, it was identified that an upregulation of H19 induced epithelial-to-mesenchymal transition. In conclusion, H19 has a significant role in the development of EC and may serve as a potential prognostic marker and therapeutic target for EC. |
| Pubmed ID | 26171017 |
| Year | 2015 |
| Title | Upregulation of H19 promotes invasion and induces epithelial-to-mesenchymal transition in esophageal cancer. |
External Links
| Links for H19 | GenBank HGNC NONCODE |
| Links for esophageal cancer | OMIM COSMIC |