Basic Information
| LncRNA/CircRNA Name | AK022798 |
| Synonyms | C1orf74, URLC4, FLJ25078 |
| Region | GRCh38_1:209779208-209784559 |
| Ensemble | ENSG00000162757 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Western blot etc. |
| Sample | cell lines (SGC7901, BGC823, SGC7901/DDP, BGC823/DDP etc.) |
| Expression Pattern | up-regulated |
| Function Description | The expression of lncRNA AK022798 was significantly higher in all pcDNA3-Notch 1 plasmid treatment groups than in the pcDNA3 plasmid treatment group. Overexpression of lncRNA AK022798 promotes SGC7901/DDP and BGC823/DDP cells apoptosis.the expression of MRP1 and P-glycoprotein decreased significantly in SGC7901/DDP and BGC823/DDP cells, and their apoptosis as well as the expressions of caspase 3 and caspase 8. |
| Pubmed ID | 25763542 |
| Year | 2015 |
| Title | Notch 1 promotes cisplatin-resistant gastric cancer formation by upregulating lncRNA AK022798 expression. |
External Links
| Links for AK022798 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |