Basic Information
| LncRNA/CircRNA Name | H19 |
| Synonyms | H19, ASM, ASM1, BWS, D11S813E, LINC00008, NCRNA00008, WT2 |
| Region | GRCh38_11:1995176-2001470 |
| Ensemble | ENSG00000130600 |
| Refseq | NR_002196 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | papillary thyroid cancer |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot |
| Sample | cell line (Nthyori 3-1, K1,B-CPAP, IHH4), PTC tissues |
| Expression Pattern | down-regulated |
| Function Description | H19 overexpression reduced PTC cell proliferation and migration. It also inhibited the expression of tumor necrosis factor receptor 2.H19 inhibits tumorigenesis in PTC and may be utilized as a potential diagnostic tool for PTC. |
| Pubmed ID | 29287713 |
| Year | 2018 |
| Title | Downregulation of long noncoding RNA H19 contributes to the proliferation and migration of papillary thyroid carcinoma. |
External Links
| Links for H19 | GenBank HGNC NONCODE |
| Links for papillary thyroid cancer | OMIM COSMIC |