Basic Information
| LncRNA/CircRNA Name | H19 |
| Synonyms | H19, ASM, ASM1, BWS, D11S813E, LINC00008, NCRNA00008, WT2 |
| Region | GRCh38_11:1995176-2001470 |
| Ensemble | ENSG00000130600 |
| Refseq | NR_002196 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | neuroblastoma |
| ICD-0-3 | NA |
| Methods | qRT-PCR, Western blot |
| Sample | Human neuroblastoma cell line (SH-SY5Y), 293T cells |
| Expression Pattern | up-regulated |
| Function Description | Expressions of lncRNA-H19 and miR-675 were upregulated in neuroblastoma cells,and were downregulated by AP.AP was also identified to upregulate CD44.We next found AP affected SH-SY5Y cells through downregulating miR-675.Key kinases in the PI3K/AKT and JAK/STAT pathways were downregulated by AP stimulation,while these downregulations were abrogated by miR-675 overexpression. KIF1B isoform B (KIF1BB) is proved to be a target of miR-675. |
| Pubmed ID | 29465760 |
| Year | 2018 |
| Title | Angelica sinensis polysaccharide inhibits proliferation, migration, and invasion by downregulating microRNA-675 in human neuroblastoma cell line SH-SY5Y. |
External Links
| Links for H19 | GenBank HGNC NONCODE |
| Links for neuroblastoma | OMIM COSMIC |