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Basic Information

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis	apoptosis	Drug
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	lung adenocarcinoma
ICD-0-3	C34
Methods	qPCR, Western blot, Luciferase reporter assay, RNA interference
Sample	Normal lung cell line HFL1 and lung adenocarcinoma cell lines A549, H1299, PC9, PG49 and NCl-H1975, Lung adenocarcinoma tissues and adjacent tissues
Expression Pattern	up-regulated
Function Description	LncRNA H19 and methylation of CDH1 were highly expressed in lung adenocarci- noma tissues. A549 cells with silencing of lncRNA H19, overexpression of CDH1 or reduced CDH1 methylation by demethylating agent 5-Az had suppressed cell prolif- eration, sphere-forming ability, apoptosis, migration and invasion, in addition to in- hibited EMT process. Silencing lncRNA H19 could reduce methylation level of CDH1. In vivo, A549 cells with silencing lncRNA H19, overexpression of CDH1 or reduced CDH1 methylation exhibited low tumorigenicity, reflected by the smaller tumour size and lighter tumour weight.
Pubmed ID	31317666
Year	2019
Title	Long non-coding RNA H19 is responsible for the progression of lung adenocarcinoma by mediating methylation-dependent repression of CDH1 promoter

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