Basic Information
| LncRNA/CircRNA Name | H19 |
| Synonyms | NA |
| Region | GRCh38_11:1995176-2001470 |
| Ensemble | ENSG00000130600 |
| Refseq | NR_002196 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | Retinoblastoma |
| ICD-0-3 | C69.2 |
| Methods | qPCR, Western blot, Luciferase reporter assay, etc. |
| Sample | Human RB Y79 cell line |
| Expression Pattern | up-regulated |
| Function Description | LncRNA-H19 knockdown repressed cell viability, migration and invasion while promoted apoptosis in Y79 cells. miR-143 was a downstream factor of lncRNA-H19, and its inhibition reversed the effects of lncRNAH19 silence on Y79 cells. RUNX2 was a target gene of miR-143, and miR-143 was found to affect Y79 cells via down-regulation of RUNX2. Phosphorylation of key kinases related in the PI3K/AKT/mTOR pathways was reduced by miR-143 via regulation of RUNX2 |
| Pubmed ID | 30551533 |
| Year | 2019 |
| Title | Knockdown of lncRNA-H19 Inhibits Cell Viability, Migration and Invasion While Promotes Apoptosis via microRNA-143/RUNX2 Axis in Retinoblastoma |
External Links
| Links for H19 | GenBank HGNC NONCODE |
| Links for Retinoblastoma | OMIM COSMIC |