Basic Information
| LncRNA/CircRNA Name | AK021443 |
| Synonyms | HELLS, ICF4, LSH, Nbla10143, PASG, SMARCA6 |
| Region | GRCh38_10:94501434-94613905 |
| Ensemble | ENSG00000119969 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, Western blot etc |
| Sample | hepatocellular carcinoma tissues, cell lines (Bel-7402, Sk-Hep1, HepG2, Huh-7, and Bel-7404) |
| Expression Pattern | up-regulated |
| Function Description | Hepatoma cell nucleus increased in HCC tissues compared with normal liver tissues. AK021443 expression was increased in HCC tissues and cell lines. Knockdown of AK021443 significantly reduced HepG2 and Bel-7402 cell proliferation, invasion, and migration. Furthermore, inhibition of AK021443 in HepG2 and Bel-7402 cells significantly repressed EMT ability. Knockdown of AK021443 in vivo also significantly inhibited tumor growth with decreased Ki-67 levels and EMT phenotype in tumor tissues. However, these functions could be reversed by overexpression of AK021443. AK021443 significantly controlled HepG2 and Bel-7402 cell proliferation, colony formation, invasion, and migration by repressing EMT, which might provide a potential therapeutic target for HCC diagnosis. |
| Pubmed ID | 29638164 |
| Year | 2018 |
| Title | Long Noncoding RNA AK021443 Promotes Cell Proliferation and Migration by Regulating Epithelial-Mesenchymal Transition in Hepatocellular Carcinoma Cells. |
External Links
| Links for AK021443 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |