Basic Information
| LncRNA/CircRNA Name | H19 |
| Synonyms | NA |
| Region | GRCh38_11:1995176-2001470 |
| Ensemble | ENSG00000130600 |
| Refseq | NR_002196 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | Oxaliplatin | |
| Variant | Cell Growth | Circulating | 2 | ||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | RNA-seq, qPCR, Western blot, RIP, Luciferase reporter assays |
| Sample | colorectal cancer tissues, cell lines (HCT116, SW480) |
| Expression Pattern | up-regulated |
| Function Description | H19 was highly expressed in the tumor tissues of CAC mice compared with the expression in normal colon tissues. The up-regulation of H19 was also confirmed in CRC patient samples at different tumor node metastasis (TNM) stages. H19 was enriched in CAF-derived conditioned medium and exosomes, H19 activated the ?-catenin pathway via acting as a competing endogenous RNA sponge for miR-141 in CRC,LncRNA H19 promotes the stemness and oxaliplatin resistance of colorectal cancer. The cell apoptosis assay confirmed that the oxaliplatin resistance of SW480 cells was further enhanced by overexpression of H19. |
| Pubmed ID | 30083271 |
| Year | 2018 |
| Title | Carcinoma-associated Fibroblasts Promote the Stemness and Chemoresistance of Colorectal Cancer by Transferring Exosomal lncRNA H19. |
External Links
| Links for H19 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |