Basic Information
| LncRNA/CircRNA Name | H19 |
| Synonyms | NA |
| Region | GRCh38_11:1995176-2001470 |
| Ensemble | ENSG00000130600 |
| Refseq | NR_002196 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | metformin | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Western blot, Cell invasion assay, Cell migration assay Animal experiments |
| Sample | cell lines(AGS,SGC7901) |
| Expression Pattern | up-regulated |
| Function Description | we found that metformin significantly inhibited the cellular functions of gastric cancer cells through Cell Counting Kit-8 and invasion assays. We found that lncRNA H19 was greatly downregulated in gastric cancer cells treated with metformin using lncRNA microassays. H19 is shown to be overexpressed in gastric cancer tissues, with increased expression of H19 relating to advanced pathological tumor stage and pathological tumor node metastasis stage. Metformin inhibits the proliferation of gastric cancer cell growth of AGS and SGC7901. |
| Pubmed ID | 30192003 |
| Year | 2018 |
| Title | Long noncoding RNA H19 participates in metformin-mediated inhibition of gastric cancer cell invasion. |
External Links
| Links for H19 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |