Basic Information
| LncRNA/CircRNA Name | H19 |
| Synonyms | NA |
| Region | GRCh38_11:1995176-2001470 |
| Ensemble | ENSG00000130600 |
| Refseq | NR_002196 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | esophageal cancer |
| ICD-0-3 | C15 |
| Methods | qRT-PCR, Western blotting, in vitro knockdown etc. |
| Sample | EC tissues and corresponding non-tumor control tissues, Human EC cells (Eca109, kyse410, kyse510, TE-1, TE-5), human normal esophageal epithelial cells (HEEC), and HEK293T cells |
| Expression Pattern | NA |
| Function Description | Our results showed that the mRNA level of H19 was significantly increased in EC versus normal tissue.Knockdown of lncRNA H19 repressed cell proliferation, migration and invasion as well as EMT and metastasis via STAT3-EZH2-?-catenin pathway, while lncRNA H19 regulated STAT3 negatively regulated let-7c in EC cell lines |
| Pubmed ID | 31102664 |
| Year | 2019 |
| Title | LncRNA H19 Promotes Epithelial Mesenchymal Transition and Metastasis of Esophageal Cancer via STAT3/EZH2 Axis |
External Links
| Links for H19 | GenBank HGNC NONCODE |
| Links for esophageal cancer | OMIM COSMIC |