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Basic Information

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis	apoptosis	Drug	steroid hormones
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	uterine leiomyoma
ICD-0-3	C57.4
Methods	qRT-PCR , in vitro knockdown etc.
Sample	fibroid and myometrial tissues ,cell lines(ht-UtLM cells ,primary UtLM-1 and UtLM-2 cells)
Expression Pattern	up-regulated
Function Description	Expression levels of GASL1 in prostate tissues and sera from patients with PC and from healthy subjects were detected.GASL1 was significantly downregulated in the tissue and serum of patients with PC compared to those of healthy subjects. In addition, GASL1 was used to distinguish patients with PC from healthy controls, and low expression levels of GASL1 were associated with short survival time. Expression levels of GASL1 were significantly associated with tumor size. GASL1 overexpression inhibited PC cell growth. Overexpression of GASL1 upregulated Bcl-2 expression and downregulated GLUT-1 expression.
Pubmed ID	31089260
Year	2019
Title	H19 lncRNA Identified as a Master Regulator of Genes That Drive Uterine Leiomyomas

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