Basic Information
| LncRNA/CircRNA Name | H19 |
| Synonyms | NA |
| Region | GRCh38_11:1995176-2001470 |
| Ensemble | ENSG00000130600 |
| Refseq | NR_002196 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | pancreatic neuroendocrine tumor |
| ICD-0-3 | C25 |
| Methods | qRT-PCR , RNA-seq , Western blot , RIP , in vitro knockdown etc. |
| Sample | tumors and their corresponding adjacent normal tissues as well as metastatic tissues ,QGP-1 cell line |
| Expression Pattern | up-regulated |
| Function Description | H19 was significantly upregulated in pNEN tissues with malignant behaviors, and the upregulation predicted poor prognosis in pNENs.H19 overexpression promoted tumor growth and metastasis, whereas H19 knockdown led to the opposite phenotypes.H19 interacted with VGF, which was significantly upregulated in pNENs, and higher VGF expression was markedly related to poor differentiation and advanced stage.Furthermore, VGF was downregulated when H19 was knocked down, and VGF promoted cell proliferation, migration and invasion.H19 activated PI3K/AKT/CREB signaling and promoted pNEN progression by interacting with VGF. |
| Pubmed ID | 31117050 |
| Year | 2019 |
| Title | lncRNA H19 Binds VGF and Promotes pNEN Progression via PI3K/AKT/CREB Signaling |
External Links
| Links for H19 | GenBank HGNC NONCODE |
| Links for pancreatic neuroendocrine tumor | OMIM COSMIC |