Basic Information
| LncRNA/CircRNA Name | H19 |
| Synonyms | NA |
| Region | GRCh38_11:1995176-2001470 |
| Ensemble | ENSG00000130600 |
| Refseq | NR_002196 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | Hodgkin's lymphoma |
| ICD-0-3 | NA |
| Methods | qRT-PCR , Western blot , in vitro knockdown etc. |
| Sample | HL tissues and reactive hyperplasia of lymph nodes (RH) tissues ,Classical Hodgkin?? lymphoma (CHL), diffuse large B-cell lymphoma cell line Ly1, B-cell derived cell line L428 and mouse B-cell derived cell line A20 |
| Expression Pattern | up-regulated |
| Function Description | H19 was overexpressed in HL tissues and cell lines compared with those of controls. HL patients with huge lump and in Ann Arbor stage III-IV presented higher expression of H19. Besides, H19 expression was negatively correlated to overall survival (OS) of HL patients.H19 downregulation decreased proliferation and viability of HL cells. AKT expression was upregulated in HL tissues compared with RH tissues, and was positively regulated by H19.H19 overexpression upregulated protein expression of AKT in HL cells. |
| Pubmed ID | 31128034 |
| Year | 2019 |
| Title | Long Non-Coding RNA H19 Promotes Proliferation of Hodgkin's Lymphoma via AKT Pathway |
External Links
| Links for H19 | GenBank HGNC NONCODE |
| Links for Hodgkin's lymphoma | OMIM COSMIC |