Basic Information
| LncRNA/CircRNA Name | H19 |
| Synonyms | NA |
| Region | GRCh38_11:1995176-2001470 |
| Ensemble | ENSG00000130600 |
| Refseq | NR_002196 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | retinoblastoma |
| ICD-0-3 | C69.2 |
| Methods | qPCR, Western blot, in vitro knockdown |
| Sample | retinoblastoma tissues, cell lines (Y79 and Weri-Rb1) |
| Expression Pattern | up-regulated |
| Function Description | H19 may serve a critical oncogenic function in the progression of retinoblastoma, as lncRNA H19 levels were markedly increased in retinoblastoma cells and tissues compared with corresponding controls. In addition, patients with retinoblastoma with increased lncRNA H19 expression experienced poorer survival time compared with those with decreased lncRNA H19 levels. Knockdown of lncRNA H19 significantly suppressed retinoblastoma cell proliferation, migration and invasion in vitro and in vivo. Knockdown of lncRNA H19 promotes cell apoptosis. |
| Pubmed ID | 29805578 |
| Year | 2018 |
| Title | Long Non-Coding RNA H19 Regulates Viability and Metastasis, and Is Upregulated in Retinoblastoma |
External Links
| Links for H19 | GenBank HGNC NONCODE |
| Links for retinoblastoma | OMIM COSMIC |