Detail

Basic Information

LncRNA/CircRNA Name	H19
Synonyms	NA
Region	GRCh38_11:1995176-2001470
Ensemble	ENSG00000130600
Refseq	NR_002196

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis		Drug
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	prostate cancer
ICD-0-3	C61.9
Methods	qPCR, Western blot, Microarray
Sample	T-ALL cell lines,PCa cell lines
Expression Pattern	differential expression
Function Description	Overexpression or knockdown of PIM in these T-ALL cell lines controlled the level of H19 and regulated the methylation of the H19 promoter, suggesting a mechanism by which PIM controls H19 transcription. the knockdown of H19 blocked the ability of PIM to induce stem cell genes in T-ALL cells, suggesting a novel signal transduction cascade.
Pubmed ID	32146726
Year	2020
Title	PIM protein kinases regulate the level of the long noncoding RNA H19 to control stem cell gene transcription and modulate tumor growth

External Links

Links for H19	GenBank HGNC NONCODE
Links for prostate cancer	OMIM COSMIC