Basic Information
| LncRNA/CircRNA Name | GRP78 |
| Synonyms | NA |
| Region | GRCh38_9:125234853-125241330 |
| Ensemble | ENSG00000044574 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | prostate cancer |
| ICD-0-3 | C61.9 |
| Methods | qPCR etc. |
| Sample | cell line (PC3PCA+ ) |
| Expression Pattern | up-regulated |
| Function Description | Three proteins were found down-regulated and 7 proteins up-regulated in PC3PCA+ cells compared to PC3NC cells,including GRP78.Higher GRP78 was also found in PCa clinical specimens.This study confirmed that in PCa, PCA3 plays a pro-cancer role through promoting cell proliferation, migration and invasion while inhibiting cell apoptosis. This process might involve the up-regulation of GRP78.GRP78 was also reported to be preferentially expressed in the camptothecin (CPT)- resistant PC3 prostate cancer cell line in comparison to the CPT-sensitive LNCaP prostate cancer cell line, which indicated its involvement in chemotherapy resistant in PCa. |
| Pubmed ID | 28739722 |
| Year | 2017 |
| Title | GRP78 Participates in PCA3-regulated Prostate Cancer Progression. |
External Links
| Links for GRP78 | GenBank HGNC NONCODE |
| Links for prostate cancer | OMIM COSMIC |