Basic Information
| LncRNA/CircRNA Name | GPC3-AS1 |
| Synonyms | NA |
| Region | GRCh38_1:29554-31109 |
| Ensemble | |
| Refseq | NR_148713 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cervical cancer |
| ICD-0-3 | C53 |
| Methods | in vitro knockdown , Western blot etc. |
| Sample | human CC cell lines (HeLa, SiHa, C-33A and CaSki) ,normal human cervical epithelial immortalized cell CRL-2614 |
| Expression Pattern | up-regulated |
| Function Description | GPC3-AS1 was up-regulated in CC cells compared to normal cells.The negative effect of GPC3-AS1 depletion on CC cell proliferation and migration.GPC3-AS1 positively regulated its nearby gene glypican 3 (GPC3).Significant up-regulation of GPC3 was also observed in CC cells, consistently with GPC3-AS1. In addition, GPC3-AS1 and GPC3 synergistically promoted the proliferative and migratory abilities of CC cells. ELK1 acted as the transcription activator of GPC3-AS1 and GPC3, thus contributing to their up-regulation in CC cells. ELK1-induced GPC3-AS1/GPC3 axis promoted cell proliferation and migration in CC. |
| Pubmed ID | 31168873 |
| Year | 2019 |
| Title | ELK1-activated GPC3-AS1/GPC3 Axis Promotes the Proliferation and Migration of Cervical Cancer Cells |
External Links
| Links for GPC3-AS1 | GenBank HGNC NONCODE |
| Links for cervical cancer | OMIM COSMIC |