Basic Information
| LncRNA/CircRNA Name | GNG12-AS1 |
| Synonyms | GNG12-AS1 |
| Region | GRCh38_1:67832303-68202987 |
| Ensemble | ENSG00000232284 |
| Refseq | NR_040077 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, RNAi, ChIP etc. |
| Sample | cell lines (HB2, SUM159, MCF7, K562, Hs27, CAL51, MCF10A etc.) |
| Expression Pattern | down-regulated |
| Function Description | We report that GNG12-AS1 is coexpressed with DIRAS3 in several tissues and coordinately downregulated with DIRAS3 in breast cancers. In breast cancer cell lines with loss of DIRAS3 imprinting, DIRAS3 and GNG12-AS1 are silenced in cis and the remaining GNG12-AS1 transcripts are predominantly monoallelic. |
| Pubmed ID | 23871723 |
| Year | 2013 |
| Title | Imprinted chromatin around DIRAS3 regulates alternative splicing of GNG12-AS1, a long noncoding RNA. |
External Links
| Links for GNG12-AS1 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |