Basic Information
| LncRNA/CircRNA Name | GMAN |
| Synonyms | B61, EFL1, GMAN, ECKLG, EPLG1, LERK1, LERK-1, TNFAIP4 |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | Microarray, qPCR, Western blot, other |
| Sample | GC tissues and cell line (BGC-823, SGC-7901, MKN45, GES-1, HGC-27, MGC-803, AGS cells ) |
| Expression Pattern | up-regulated |
| Function Description | We identified an lncRNA, which we call GMAN, that is increased in gastric tumors from patients and associated with survival and formation of metastases. It regulates translation of ephrin A1 mRNA by binding competitively to GMAN-AS. Knockdown or knockout of GMAN or ephrin A1 in gastric cancer cell lines reduces their invasive activity and ability to form metastases after injection into mice.? |
| Pubmed ID | 30445010 |
| Year | 2019 |
| Title | Long Noncoding RNA GMAN, Up-regulated in Gastric Cancer Tissues, Is Associated With Metastasis in Patients and Promotes Translation of Ephrin A1 by Competitively Binding GMAN-AS. |
External Links
| Links for GMAN | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |