Basic Information
| LncRNA/CircRNA Name | GMAN |
| Synonyms | Gastric cancer metastasis associated long noncoding RNA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qRT-PCR, Western blot, RIP |
| Sample | HCC tissues |
| Expression Pattern | up-regulated |
| Function Description | lncRNA-GMAN was significantly overexpressed in HCC tissues. GMAN expression is associated with vascular invasion, histological grade, tumor, node, metastasis (TNM) stage, short overall survival, and disease-free survival. Knockdown of GMAN induced apoptosis and suppressed invasive and migration potential in vitro and vivo, whereas ectopic GMAN expression produced the opposite effect. We also found that the inhibition of apoptosis, rather than promotion of proliferation, was responsible for GMAN-enhanced cellular viability. |
| Pubmed ID | 31875526 |
| Year | 2020 |
| Title | Long Noncoding RNA GMAN Promotes Hepatocellular Carcinoma Progression by Interacting With eIF4B |
External Links
| Links for GMAN | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |