Basic Information
| LncRNA/CircRNA Name | GIHCG |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | qPCR, etc. |
| Sample | OC tissues, Ovarian epithelium cell line (IOSE-386) and OC cell lines (HEY, A2780 and HO8910) |
| Expression Pattern | up-regulated |
| Function Description | GIHCG was highly expressed, whereas microRNA-429 was lowly expressed in OC tissues than that of paracancerous tissues. OC patients with higher expression of GIHCG showed shorter OS than those with lower expression. However, OC patients with higher expression of microRNA-429 had longer OS than those with lower expression. GIHCG expression was positively correlated to microRNA-429. In vitro experiments showed that GIHCG was highly expressed in HEY, A2780 and HO8910 cells than that of IOSE-386 cells. GIHCG overexpression in HEY cells promoted cell cycle and colony formation abilities, which were reversed by microRNA- 429 overexpression. |
| Pubmed ID | 30556850 |
| Year | 2018 |
| Title | LncRNA GIHCG promotes development of ovarian cancer by regulating microRNA-429 |
External Links
| Links for GIHCG | GenBank HGNC NONCODE |
| Links for ovarian cancer | OMIM COSMIC |