Basic Information
| LncRNA/CircRNA Name | GIHCG |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qRT-PCR |
| Sample | Tumor specimens,BCa cell lines (MCF-7, MDAMB-231, MDA-MB-435S, and SKBR3) and normal mammary epithelial cell line, MCF-10A |
| Expression Pattern | up-regulated |
| Function Description | the GIHCG level was remarkably higher in the BCa tumor tissue than in adjacent ones. Compared with patients with low expression of GIHCG, patients with high expression of GIHCG had higher pathological grades and a lower overall survival. Besides, the proliferation ability of BCa cells in GIHCG knockdown group was significantly decreased compared with NC group. QRT-PCR results indicated that silencing GIHCG increased the expression of miR-1281, thereby promoting the malignant progression of BCa. |
| Pubmed ID | 31858553 |
| Year | 2019 |
| Title | LncRNA GIHCG Regulates microRNA-1281 and Promotes Malignant Progression of Breast Cancer |
External Links
| Links for GIHCG | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |