Basic Information
| LncRNA/CircRNA Name | GHET1 |
| Synonyms | GHET1, lncRNA-GHET1 |
| Region | GRCh38_7:148987527-148989432 |
| Ensemble | ENSG00000281189 |
| Refseq | NR_130107 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, western blot etc. |
| Sample | gastric cancer tissues, cell lines (BGC-823, SGC-7901, AGS, GES-1) |
| Expression Pattern | up-regulated |
| Function Description | lncRNA GHET1 promoted AGS cells activations, and the results were shown that GHET1 dysregulation might be involved in the occurrence and development of gastric cancer. These results suggested that GHET1 might be a molecular marker for the progression of gastric cancer and a molecular target for targeted therapy. Clinical data and GHET1 is significantly up-regulated in cell lines. |
| Pubmed ID | 28577495 |
| Year | 2017 |
| Title | Knockdown of long noncoding RNA GHET1 inhibits cell activation of gastric cancer. |
External Links
| Links for GHET1 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |