Basic Information
| LncRNA/CircRNA Name | GHET1 |
| Synonyms | GHET1, lncRNA-GHET1 |
| Region | GRCh38_7:148987527-148989432 |
| Ensemble | ENSG00000281189 |
| Refseq | NR_130107 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, RNAi, Western blot, Flow cytometry assay, Cell proliferation assay etc. |
| Sample | CRC tissues, cell lines (Lovo, HCT-116, Caco-2) |
| Expression Pattern | up-regulated |
| Function Description | We found that GHET1 expression was significantly increased in the CRC samples compared with adjacent tissues. Furthermore, the cancer tissues had higher GHET1 mRNA levels than their matched adjacent tissues. GHET1 expression was also significantly increased in the CRC cell lines. Downregulation of GHET1 mediated by shRNA suppressed the proliferation, cell cycle arrest, migration, and invasion of colorectal cancer cells in vitro. In addition, inhibition of GHET1 reversed the epithelialmesenchymal transition in colorectal cancer cell lines. |
| Pubmed ID | 27931286 |
| Year | 2016 |
| Title | Knockdown of Long Noncoding RNA GHET1 Inhibits Cell Proliferation and Invasion of Colorectal Cancer. |
External Links
| Links for GHET1 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |