Basic Information
| LncRNA/CircRNA Name | GHET1 |
| Synonyms | NA |
| Region | GRCh38_7:148987527-148989432 |
| Ensemble | ENSG00000281189 |
| Refseq | NR_130107 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot etc |
| Sample | osteosarcoma tissues,cell lines( OS U2OS, MG-63 and SaOs-2 , hFOB) |
| Expression Pattern | up-regulated |
| Function Description | lncGHET1 expression was significantly upregulated in OS cell lines compared with in an osteoblastic cell line according to the RT-qPCR assay. The results of a knockdown functional experiment suggested that inhibition of lncGHET1 attenuated cell proliferation, migration, invasion and epithelial-to-mesenchymal transition, and promoted apoptosis, partly through regulating the Wnt/?-catenin signaling pathway in OS. |
| Pubmed ID | 32319657 |
| Year | 2020 |
| Title | Long non-coding RNA GHET1 promotes osteosarcoma development and progression via Wnt/?-catenin signaling pathway. |
External Links
| Links for GHET1 | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |