Basic Information
| LncRNA/CircRNA Name | GEHT1 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | qRT-PCR , Western blot , in vitro knockdown etc. |
| Sample | normal ovary and ovarian cancer tissues ,normal human ovarian surface epithelial cells normal epithelial ovarian epithelial cells (HOSEpiC) and ovarian cancer cell lines(OVCAR3, SKOV3, 3AO and A2780) |
| Expression Pattern | up-regulated |
| Function Description | GHET1 was overexpressed in ovarian cancer tissues and cell lines. Up-regulation of GHET1 was positively correlated with the tumor size and metastasis of the ovarian cancer patients.Overexpression of GEHT1 significantly promoted the proliferation and colony formation of ovarian cancer cells.GHET1 was found to interact with the E3 ubiquitin ligase von Hippel-Lindau (VHL), which consequently blocked VHL-mediated degradation of hypoxia-inducible factor-1? (HIF1?) and enhanced the protein level of HIF1? in ovarian cancer cells.The up-regulated HIF1? promoted the glucose uptake and lactate generation of ovarian cancer cells. |
| Pubmed ID | 30988076 |
| Year | 2019 |
| Title | Long Non-Coding RNA GEHT1 Promoted the Proliferation of Ovarian Cancer Cells via Modulating the Protein Stability of HIF1? |
External Links
| Links for GEHT1 | GenBank HGNC NONCODE |
| Links for ovarian cancer | OMIM COSMIC |