Basic Information
| LncRNA/CircRNA Name | GCRL1 |
| Synonyms | SMIM25??INC01272 |
| Region | GRCh38_20: 50267486-50279795 |
| Ensemble | ENSG00000224397 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, western blot, Luciferase reporter assay etc. |
| Sample | gastric cancer tissues, cell line SGC-7901 |
| Expression Pattern | differential expression |
| Function Description | In this study, we identified the abundantly expressed lncRNA, RP11-290F20.3, in GC cells and patient tumor tissues. We named this lncRNA as GC-related lncRNA1 (GCRL1), which could regulate gastric cell proliferation and metastasis, both in vitro and in vivo. Further, GCRL1 promoted the cell proliferation and metastasis by sponging miR-885-3p and hence, positively regulating CDK4 in GC cells. |
| Pubmed ID | 29789536 |
| Year | 2018 |
| Title | Long noncoding RNA gastric cancer-related lncRNA1 mediates gastric malignancy through miRNA-885-3p and cyclin-dependent kinase 4 |
External Links
| Links for GCRL1 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |