Basic Information
| LncRNA/CircRNA Name | GCRL1 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Western blot, Luciferase reporter assay, in vitro knockdown |
| Sample | gastric cancer tissues, cell lines (SGC-7901, GES-1, MGC-803, BGC-823, and AGS) |
| Expression Pattern | up-regulated |
| Function Description | We identified the abundantly expressed lncRNA, RP11-290F20.3, in GC cells and patient tumor tissues. We named this lncRNA as GC-related lncRNA1 (GCRL1), which could regulate gastric cell proliferation and metastasis, both in vitro and in vivo. Mechanistically, miRNA-885-3p (miR-885-3p) could inhibit the cell proliferation and metastasis in GC by negatively regulating the expression of cyclin-dependent kinase 4 (CDK4) at the post-transcriptional level. Further, GCRL1 promoted the cell proliferation and metastasis by sponging miR-885-3p and hence, positively regulating CDK4 in GC cells. |
| Pubmed ID | 29789536 |
| Year | 2018 |
| Title | Long Noncoding RNA Gastric Cancer-Related lncRNA1 Mediates Gastric Malignancy Through miRNA-885-3p and Cyclin-Dependent Kinase 4 |
External Links
| Links for GCRL1 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |