Basic Information
| LncRNA/CircRNA Name | GClnc1 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | bladder cancer |
| ICD-0-3 | C67 |
| Methods | qPCR, Western blot |
| Sample | Human bladder cancer cells (T24, 5637, UM-UC-3, and J82) and SV40-immortalized human uroepithelium 1 cell line, bladder cancer tissues and matched paracarcinoma tissues |
| Expression Pattern | up-regulated |
| Function Description | lncRNA, gastric cancer-associated lncRNA1 (GClnc1), which was in high abundance in bladder cancer tissues and its expression was related to poor survival rates in patients with bladder cancer.In vitroandin vivo assays showed thatGClnc1 significantly promoted cell proliferation,metastasis, and invasiveness in bladder cancer. Mechanistically, we first found that GClnc1 bound to LIN28B and promoted the expression of myelocytomatosis proto-oncogene (MYC) through the LIN28B/let-7a/MYC pathway. |
| Pubmed ID | 31298933 |
| Year | 2019 |
| Title | LncRNA GClnc1 promotes proliferation and invasion of bladder cancer through activation of MYC |
External Links
| Links for GClnc1 | GenBank HGNC NONCODE |
| Links for bladder cancer | OMIM COSMIC |