Basic Information
| LncRNA/CircRNA Name | GClnc1 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot assay, Luciferase reporter assay, other |
| Sample | OS tissues and cell lines (MG-63, HOS, U2OS and 143B) |
| Expression Pattern | up-regulated |
| Function Description | Functional analyses show that overexpression of GClnc1 promotes OS cells growth; whereas knockdown of GClnc1 has completely opposite effects. Consistently, overexpression of GClnc1 promotes tumorigenicity of OS cells in vivo. Mechanistically, GClnc1 directly binds to p53 and blocks the binding of p53 to acetyltransferase p300, and thereby suppresses acetylation of p53, leading to the reduced expression of p21 and BAX. |
| Pubmed ID | 30454890 |
| Year | 2018 |
| Title | Long Non-Coding RNA GClnc1 Promotes Tumorigenesis in Osteosarcoma by Inhibiting p53 Signaling |
External Links
| Links for GClnc1 | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |