Basic Information
| LncRNA/CircRNA Name | GCASPC |
| Synonyms | lnc-SOD2-1, RP1-56L9.7-001, TCONS_00011605 |
| Region | NA |
| Ensemble | ENSG00000224073 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gallbladder cancer |
| ICD-0-3 | C23.9 |
| Methods | qPCR, RIP, RNA pull-down assay, Mass Spetcrometry etc. |
| Sample | GBC tissues, cell lines (GBC-SD, SGC-996, NOZ and OCUG-1) |
| Expression Pattern | down-regulated |
| Function Description | GCASPC levels were significantly lower in gallbladder cancer than adjacent nontumor tissues and were associated with tumor size, American Joint Committee on Cancer tumor stage, and patient outcomes. GCASPC overexpression suppressed cell proliferation in vitro and in vivo, whereas GCASPC silencing had opposite effects. By RNA pull-down and mass spectrometry, we identified pyruvate carboxylase as an RNA-binding protein that associated with GCASPC. |
| Pubmed ID | 27450454 |
| Year | 2016 |
| Title | Long Noncoding RNA GCASPC, a Target of miR-17-3p, Negatively Regulates Pyruvate Carboxylase-Dependent Cell Proliferation in Gallbladder Cancer. |
External Links
| Links for GCASPC | GenBank HGNC NONCODE |
| Links for gallbladder cancer | OMIM COSMIC |