Basic Information
| LncRNA/CircRNA Name | GASL1 |
| Synonyms | LINC00899 |
| Region | GRCh38_8:102805517-102809971 |
| Ensemble | ENSG00000253669 |
| Refseq | NR_149020 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Western-Blot, other |
| Sample | NSCLC tissue and cell line( NCI-H23 and NCI-H299), blood |
| Expression Pattern | down-regulated |
| Function Description | Serum level of GASL1 was also lower in cancer patients than in healthy controls. Serum GASL1 is a sensitive diagnostic biomarker for NSCLC, and low expression level of GASL1 indicated short postoperative survival time. Overexpression of GASL1 upregulated, while GASL1 knockdown downregulated TGF-?1 expression. GASL1 overexpression inhibited, and GASL1 knockdown promoted cancer cell proliferation.lncRNA GASL1 may inhibit tumor growth of NSCLC by downregulating TGF-?1. |
| Pubmed ID | 30468472 |
| Year | 2018 |
| Title | LncRNA GASL1 Inhibits Tumor Growth of Non-Small Cell Lung Cancer by Inactivating TGF-? Pathway |
External Links
| Links for GASL1 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |