Basic Information
| LncRNA/CircRNA Name | GASL1 |
| Synonyms | NA |
| Region | GRCh38_8:102805517-102809971 |
| Ensemble | ENSG00000253669 |
| Refseq | NR_149020 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | prostate cancer |
| ICD-0-3 | C61.9 |
| Methods | RT-qPCR, Western blotting etc. |
| Sample | prostate biopsy tissues, serum samples,HPrEC human normal prostate epithelial cell line,human PC cell lines 22Rv1 and DU145 |
| Expression Pattern | up-regulated |
| Function Description | GASL1 was significantly downregulated in the tissue and serum of patients with PC compared to those of healthy subjects. In addition, GASL1 was used to distinguish patients with PC from healthy controls, and low expression levels of GASL1 were associated with short survival time. Expression levels of GASL1 were significantly associated with tumor size. GASL1 overexpression inhibited PC cell growth. Overexpression of GASL1 upregulated Bcl-2 expression and downregulated GLUT-1 expression. |
| Pubmed ID | 31186749 |
| Year | 2019 |
| Title | LncRNA GASL1 Inhibits Growth and Promotes Expression of Apoptosis-Associated Proteins in Prostate Carcinoma Cells Through GLUT-1 |
External Links
| Links for GASL1 | GenBank HGNC NONCODE |
| Links for prostate cancer | OMIM COSMIC |