Basic Information
| LncRNA/CircRNA Name | GASL1 |
| Synonyms | NA |
| Region | GRCh38_8:102805517-102809971 |
| Ensemble | ENSG00000253669 |
| Refseq | NR_149020 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qRT-PCR , Western blot , in vitro knockdown etc. |
| Sample | glioma tissues, paired adjacent healthy tissues??erum samples |
| Expression Pattern | down-regulated |
| Function Description | Glioma tumor tissue exhibited significantly lower GASL1 expression compared with in adjacent healthy tissue. Serum levels of GASL1 were lower in patients compared with in healthy controls.Serum GASL1 was identified to be a sensitive biomarker for glioma cancer, and a low expression level of GASL1 was associated with a decreased postoperative survival rate.In glioma cell lines with GASL1 overexpression, TGF-?1 expression was decreased and proliferation was inhibited. GASL1 knockdown in glioma cell lines led to increased TGF-?1 expression and proliferation. |
| Pubmed ID | 31186801 |
| Year | 2019 |
| Title | Long Non-Coding RNA GASL1 May Inhibit the Proliferation of Glioma Cells by Inactivating the TGF-? Signaling Pathway |
External Links
| Links for GASL1 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |