Basic Information
| LncRNA/CircRNA Name | GAS8-AS1 |
| Synonyms | NA |
| Region | GRCh38_16:90028908-90029901 |
| Ensemble | ENSG00000221819 |
| Refseq | NR_122031 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | papillary thyroid cancer |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, in vitro knockdown etc. |
| Sample | cell line (BCPAP, Nthy-ori-3-1, K1), PTC tissues |
| Expression Pattern | down-regulated |
| Function Description | Overexpression of GAS8-AS1 inhibited proliferation, significantly increased the ratio of LC3-II/LC3-I, and reduced p62 expression, whereas GAS8-AS1 knockdown demonstrated opposite effects.silencing of ATG5 attenuated autophagy activation and rescued the inhibition of cell proliferation caused by GAS8-AS1. |
| Pubmed ID | 29327301 |
| Year | 2017 |
| Title | LncRNA GAS8-AS1 inhibits cell proliferation through ATG5-mediated autophagy in papillary thyroid cancer. |
External Links
| Links for GAS8-AS1 | GenBank HGNC NONCODE |
| Links for papillary thyroid cancer | OMIM COSMIC |