Basic Information
| LncRNA/CircRNA Name | GAS8-AS1 |
| Synonyms | NA |
| Region | GRCh38_16:90028908-90029901 |
| Ensemble | ENSG00000221819 |
| Refseq | NR_122031 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, RIP, RNAi, other |
| Sample | HCC tissues and cel lines (HepG2, SMMC7721) |
| Expression Pattern | down-regulated |
| Function Description | We detected a CpG island in the GAS8 promoter, but lncRNA GAS8-AS1 did not affect DNA methylation at this GAS8 promoter site. Moreover, we identified two GAS8-AS1-interacting proteins, mixed-lineage leukemia 1 (MLL1), a histone 3 Lys-4 (H3K4) methyltransferase, and its partner WD-40 repeat protein 5 (WDR5). RNA pulldown, ChIP, and RNA immunoprecipitation assays revealed that GAS8-AS1 is required for maintaining the GAS8 promoter in an open chromatin state by recruiting the MLL1/WDR5 complex and for enhancing RNA polymerase II activity and GAS8 transcription. Of note, GAS8-AS1-dependent GAS8 hyperactivation inhibited malignant transformation of hepatocytes |
| Pubmed ID | 30228180 |
| Year | 2018 |
| Title | The Long Noncoding RNA GAS8-AS1 Suppresses Hepatocarcinogenesis by Epigenetically Activating the Tumor Suppressor GAS8 |
External Links
| Links for GAS8-AS1 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |